A new Sherriff in town: Vascular calcium meets its match.

Severe vascular calcification in femoropopliteal disease is associated with worse short- and long-term outcomes. Intravascular lithotripsy therapy causes micro-fractures in intimal and medial calcium at low-pressure inflations. This results acute luminal gain, with minimal vessel injury in calcified lesions. Ongoing trials will determine the benefit of intravascular lithotripsy as an adjunct to drug coated balloons in peripheral vascular disease.