Data-driven modeling of core gene regulatory network underlying leukemogenesis in IDH mutant AML.

Ataur KatebiXiaowen ChenSheng LiMingyang Lu

Published in: bioRxiv : the preprint server for biology (2023)

A combined bioinformatics and systems-biology modeling approach is designed to model a transcriptional regulatory network for AML with IDH mutations. Network modeling identifies key regulators DNMT1 and E2F1, which is supported by patient survival data.

Keyphrases

acute myeloid leukemia
transcription factor
low grade
wild type
dna methylation
gene expression
case report
genome wide
allogeneic hematopoietic stem cell transplantation
big data
acute lymphoblastic leukemia
deep learning
high grade