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Effect of obesity on dolutegravir exposure in Black Southern African adults living with HIV.

Enkosi MondlekiClifford George BandaNomathemba C ChandiwanaSimiso Mandisa SokhelaLubbe WiesnerWillem Daniel Francois VenterGary MaartensPhumla Z Sinxadi
Published in: Southern African journal of HIV medicine (2022)
Dolutegravir exposure was marginally lower in participants with obesity, but this is not clinically significant. Our findings suggest that there is no need to dose adjust dolutegravir in people with obesity.
Keyphrases
  • insulin resistance
  • metabolic syndrome
  • weight loss
  • high fat diet induced
  • type diabetes
  • weight gain
  • antiretroviral therapy
  • hiv infected patients
  • adipose tissue
  • body mass index
  • physical activity