Enabling high-sensitivity live single-cell mass spectrometry using an integrated electrical lysis and nano electrospray ionization interface.

Kanchana PandianLuís Daniel de Aguiar Homem E Almeida de MatosLaura A HetzelRaphaël ZwierPeter van VeldhuizenCharelle SchubertJayaprakash KaruppusamyAmy C HarmsAhmed AliThomas Hankemeier

Published in: Analytica chimica acta (2024)

Overall, our results demonstrate that the newly incorporated SCEL-nS platform achieved higher sensitivities compared to traditional live single cell analysis methods.

Keyphrases

single cell
rna seq
high throughput
mass spectrometry
high resolution
dengue virus
capillary electrophoresis
high performance liquid chromatography
ms ms