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Desulfurative Ni-Catalyzed Reductive Cross-Coupling of Benzyl Mercaptans/Mercaptoacetates with Aryl Halides.

Che-Ming HsuShao-Chi LeeHao-En TsaiYong-Ting TsaoCheng-Lin ChanShinje MiñozaZong-Nan TsaiLi-Yun LiHsuan-Hung Liao
Published in: The Journal of organic chemistry (2022)
The C-S activation and sulfur removal from native thiols is challenging, which limits their application as feedstock materials in organic synthesis despite their natural abundance. Herein, we introduce a per-/polyfluoroaryl moiety, which serves as a redox-active scaffold, into sp 3 -hybridized thiols to activate the C-S bond. Using a Ni catalyst with MgBr 2 as an additive, the S group can be removed to yield an aliphatic radical that can react with an aryl halide in a reductive cross-coupling.
Keyphrases
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