Glycol chitosan-based tacrolimus-loaded nanomicelle therapy ameliorates lupus nephritis.

Chang Seong KimAnsuja Pulickal MathewArathy VasukuttySaji UthamanSoo Yeon JooEun Hui BaeSeong Kwon MaIn-Kyu ParkYong-Soo Kim

Published in: Journal of nanobiotechnology (2021)

Our study indicates that weekly treatment with the HGC-TAC nanomicelles reduces kidney injury resulting from lupus nephritis by preventing inflammation, fibrosis, and apoptosis. This advantage of a new therapeutic modality using kidney-targeted HGC-TAC nanocarriers may improve drug adherence and provide treatment efficacy in lupus nephritis mice.

Keyphrases

drug delivery
oxidative stress
cancer therapy
stem cells
endoplasmic reticulum stress
cell death
emergency department
cell proliferation
metabolic syndrome
mouse model
adipose tissue
wound healing
cell therapy
weight loss
wild type