Prospective Analysis of urINe LAM to Eliminate NTM Sputum Screening (PAINLESS) study: Rationale and trial design for testing urine lipoarabinomannan as a marker of NTM lung infection in cystic fibrosis.

Kara M CalhounEmily ArmantroutKatie PochSilvia CaceresValerie K LovellMarion JonesKenneth C MalcolmBrian VestalEmily WheelerNoel RysavyJordan ManzerIbrahim AboellailDelphi ChatterjeeJerry A Nick

Published in: medRxiv : the preprint server for health sciences (2024)

This report describes the study design of an observational study aimed at using a urine biomarker to assist in the diagnosis of NTM lung infection in pwCF. If successful, urine LAM could be used as an adjunct to traditional sputum cultures for routine NTM screening.

Keyphrases

cystic fibrosis
mycobacterium tuberculosis
pseudomonas aeruginosa
clinical trial
lung function
clinical practice
phase iii
open label