Distinct [18F]THK5351 binding patterns in primary progressive aphasia variants.

Jolien M SchaeverbekeCharlotte EvenepoelLieven DeclercqSilvy GabelKaren MeersmansRose BruffaertsKate AdamczukEva DriesKaren Van BouwelAnne SiebenYolande PijnenburgRonald PeetersGuy BormansKoen Van LaereMichel KoolePatrick DupontRik Vandenberghe

Published in: European journal of nuclear medicine and molecular imaging (2018)

[18F]THK5351 imaging shows a topography closely matching the anatomical distribution of predicted underlying pathology characteristic of NFV and SV PPA. [18F]THK5351 binding correlates with the severity of clinical impairment.

Keyphrases

high resolution
multiple sclerosis
dna binding
binding protein
copy number
gene expression