Optimized PD-L1 scoring of gastric cancer.
Birgid Schoemig-MarkiefkaJana EschbachAndreas H ScheelAylin PamukJosef RueschoffThomas ZanderReinhard BuettnerWolfgang SchroederChristiane J BrunsHeike LoeserHakan AlakusAlexander QuaasPublished in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2021)
This is the first comprehensive study to optimize PD-L1 assessment in gastric cancer using endoscopically available tissue. The obtained PD-L1 prevalence is consistent with data of current clinical studies. Calculation of the test characteristics shows that surface biopsies can be indicative of the true PD-L1 status based on the resection specimen. However, an adequate number of biopsies is required. In this study, n = 4 biopsies yielded best results.
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