NF-κB-Dependent and -Independent (Moonlighting) IκBα Functions in Differentiation and Cancer.
Lluís EspinosaLaura MarruecosPublished in: Biomedicines (2021)
IκBα is considered to play an almost exclusive role as inhibitor of the NF-κB signaling pathway. However, previous results have demonstrated that SUMOylation imposes a distinct subcellular distribution, regulation, NF-κB-binding affinity and function to the IκBα protein. In this review we discuss the main alterations of IκBα found in cancer and whether they are (most likely) associated with NF-κB-dependent or NF-κB-independent (moonlighting) activities of the protein.
Keyphrases
- signaling pathway
- pi k akt
- lps induced
- nuclear factor
- oxidative stress
- papillary thyroid
- induced apoptosis
- epithelial mesenchymal transition
- squamous cell
- binding protein
- inflammatory response
- protein protein
- young adults
- immune response
- small molecule
- capillary electrophoresis
- dna binding
- endoplasmic reticulum stress
- mass spectrometry