Association of IL-10 gene promoter polymorphisms with susceptibility to pseudoexfoliation syndrome, pseudoexfoliative and primary open-angle glaucoma.

Ghasem FakhraieFarshid ParviniJalaledin GhanaviShima SaifPoopak Farina

Published in: BMC medical genetics (2020)

Our results demonstrated that IL-10 gene promoter polymorphisms are associated with susceptibility to PEX, PEXG and POAG in Iranian population. Considering the fact that IL-10 polymorphisms are associated with various IL-10 expressions, further research is needed to explain its involvement in these disorders and the formation of extracellular fibrillar amyloid deposits in PEX and PEXG.

Keyphrases

dna methylation
gene expression
genome wide
transcription factor
copy number
case report