The driver role of JAK-STAT signalling in cancer stemness capabilities leading to new therapeutic strategies for therapy- and castration-resistant prostate cancer.
U-Ging LoYu-An ChenJunjie CenSu DengJunghang LuoHaiyen ZhauLin HoChih-Ho LaiPing MuLeland W K ChungJer-Tsong HsiehPublished in: Clinical and translational medicine (2022)
This study provides a critical role of STAT1-IFIT5 in the acquisition of PCSC and highlights clinical translation of JAK or STAT1 inhibitors to prevent the outgrowth of t-CRPC.