Shared and Distinct Renal Transcriptome Signatures in 3 Standard Mouse Models of Chronic Kidney Disease.

Adam B Marstrand-JørgensenFrederikke Emilie SembachStine Thorhauge BakMaria OugaardMikkel Christensen-DalsgaardMartin Rønn MadsenDitte Marie JensenThomas SecherSebastian Møller Nguyen HeimbürgerLisbeth N FinkDitte HansenHenrik H HansenMette Viberg ØstergaardMichael ChristensenLouise S Dalbøge

Published in: Nephron (2024)

The UUO, uIRI, and ADI mouse models of CKD have significant commonalities in their renal global transcriptome profile. Model-specific renal transcriptional signatures should be considered when selecting the specific model in preclinical target and drug discovery.

Keyphrases

chronic kidney disease
drug discovery
genome wide
mouse model
gene expression
end stage renal disease
rna seq
single cell
transcription factor
bone marrow
peritoneal dialysis