Fibrogenesis Marker PRO-C3 Is Higher in Advanced Liver Fibrosis and Improves in Patients Undergoing Bariatric Surgery.

Pierre Bel LassenNicole NoriPierre BedossaLaurent GenserJudith Aron-WisnewskyChristine PoitouRambabu SurabattulaMette Juul NielsenMorten Asser KarsdalDiana Julie LeemingDetlef SchuppanKarine Clément

Published in: The Journal of clinical endocrinology and metabolism (2022)

PRO-C3 was associated with advanced liver fibrosis in patients with severe obesity, and decreased after BS, without being affected by ATF. These data suggest that BS prominently eliminates drivers of hepatic fibrogenesis in NAFLD.

Keyphrases

liver fibrosis
bariatric surgery
weight loss
patients undergoing
anti inflammatory
insulin resistance
metabolic syndrome
type diabetes
obese patients
electronic health record
transcription factor
early onset
weight gain
high fat diet induced
endoplasmic reticulum stress
big data
adipose tissue
body mass index