Hyperoside Alleviates High Glucose-Induced Proliferation of Mesangial Cells through the Inhibition of the ERK/CREB/miRNA-34a Signaling Pathway.

Le ZhangQian DaiLanlan HuHua YuJing QiuJiyin ZhouMin LongShiwen Zhou Kebin Zhang

Published in: International journal of endocrinology (2020)

Our cumulative results suggested that hyperoside inhibits the proliferation of SV40-MES13 cells through the suppression of the ERK/CREB/miRNA-34a signaling pathway, which provides new insight to the current investigation on therapeutic strategies for diabetic nephropathy.

Keyphrases

signaling pathway
induced apoptosis
high glucose
pi k akt
diabetic nephropathy
cell cycle arrest
endothelial cells
epithelial mesenchymal transition
cell proliferation
cell death
oxidative stress
drug induced