Proteomic identification and characterization of hepatic glyoxalase 1 dysregulation in non-alcoholic fatty liver disease.
Christos SpanosElaina M MaldonadoCiarán P FisherPetchpailin LeenutaphongErnesto Oviedo-OrtaDavid WindridgeFrancisco J SalgueroAlexandra Bermúdez-FajardoMark E WeeksCaroline EvansBernard M CorfeNaila RabbaniPaul J ThornalleyMichael H MillerHuan WangJohn F DillonAlberto QuagliaAnil DhawanEmer FitzpatrickJennifer Bernadette MoorePublished in: Proteome science (2018)
Collectively these results demonstrate the dysregulation of GLO1 in NAFLD and implicate the acetylation-ubquitination degradation pathway as the functional mechanism. Further investigation of the role of GLO1 in the molecular pathogenesis of NAFLD is warranted.
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