A mitochondria-targeted near-infrared fluorescent probe for imaging viscosity in living cells and a diabetic mice model.

Bochao ChenShumei MaoYanyan SunLiyuan SunNing DingChengde LiJin Zhou

Published in: Chemical communications (Cambridge, England) (2021)

A mitochondria-targeted near-infrared fluorescent probe NIR-V with 700 nm emission was designed to monitor cell viscosity changes with high selectivity and sensitivity, which was applied to detect the intracellular viscosity and image pancreatic tissue in a diabetic mouse model. Probe NIR-V provides an effective way to diagnose viscosity related diseases.

Keyphrases

fluorescent probe
living cells
mouse model
reactive oxygen species
cell death
cancer therapy
type diabetes
high resolution
photodynamic therapy
single cell
deep learning
stem cells
mass spectrometry
drug delivery
wound healing
drug release
quantum dots