Protective effects of glycycoumarin on liver diseases.
Enxiang ZhangShutao YinShuang ZhaoChong ZhaoMingzhu YanLihong FanHongbo HuPublished in: Phytotherapy research : PTR (2019)
Licorice, an edible and medicinal plant, has long been used to treat various diseases, including liver diseases. Glycycoumarin (GCM) is a representative coumarin compound in licorice with favorable bioavailability feature. Recent studies by us demonstrated that GCM is highly effective against alcoholic liver disease, nonalcoholic fatty liver disease, acetaminophen-induced hepatotoxicity, and liver cancer through mechanisms involved in activation of Nrf2 antioxidant system, stimulation of AMPK-mediated energy homeostasis, induction of autophagy degradation process, and inhibiting oncogenic kinase T-lymphokine-activated killer cell-originated protein kinase activity. In this review, we summarize the findings on the hepatoprotective effect of GCM, discuss the signaling pathways underlying GCM-induced protective effect on liver diseases, and propose the issues that need to be addressed to promote further development of GCM as a clinically useful hepatoprotective agent.
Keyphrases
- protein kinase
- drug induced
- signaling pathway
- liver injury
- oxidative stress
- diabetic rats
- high glucose
- cell death
- single cell
- machine learning
- endothelial cells
- deep learning
- epithelial mesenchymal transition
- transcription factor
- stem cells
- endoplasmic reticulum stress
- cell therapy
- cell proliferation
- induced apoptosis
- tyrosine kinase