CXCL8, MMP12, and MMP13 are common Biomarkers of Periodontitis and Oral Squamous Cell Carcinoma.

We identified 4 hub genes between PD and OSCC, including IL-1β, CXCL8, MMP12, and MMP13. These genes may mediate the co-morbid process of PD and OSCC through inflammation-related pathways such as the IL-17 signaling pathway. It is worth noting that CXCL8, MMP12 and MMP13 have great significance in the diagnosis and prognosis of OSCC.