The Acute Impact of Propofol on Blood-Brain Barrier Integrity in Mice.

Ehsan NozohouriYeseul AhnSumaih ZoubiDhavalkumar PatelSabrina Rahman ArchieKhondker Ayesha AkterMuhammad Bilal SiddiqueJuyang HuangThomas J AbbruscatoUlrich Bickel

Published in: Pharmaceutical research (2024)

Propofol at clinical plasma concentrations acutely increases BBB permeability, extending our previous results with volatile anesthetics to a lipophilic injectable agent. This prompts further exploration, potentially refining clinical practices and ensuring safety, especially during extended propofol infusion schemes.

Keyphrases

blood brain barrier
healthcare
primary care
liver failure
endothelial cells
respiratory failure
type diabetes
high fat diet induced
intensive care unit
drug induced