Triple A patient cells suffering from mitotic defects fail to localize PGRMC1 to mitotic kinetochore fibers.

Ramona JühlenDana LandgrafAngela HuebnerKatrin Koehler

Published in: Cell division (2018)

Our results emphasize the possibility that loss of the regulatory association between ALADIN and PGRMC2 gives rise to a depletion of PGRMC1 at kinetochore fibers. This observation may explain part of the symptoms seen in triple A syndrome patients.

Keyphrases

end stage renal disease
case report
cell cycle
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
transcription factor
cell cycle arrest
cell proliferation
patient reported outcomes
depressive symptoms
cell death