Association of GSTP1, GSTT1 and GSTM1 Gene Variants with Coronary Artery Disease in Iranian Population: A Case-Control Study.
Alemeh PourkeramatiEhsan Zare MehrjardiMasoud Dehghan TezerjaniSeyed Morteza SeifatiPublished in: International journal of general medicine (2020)
Our results suggest that the GSTM1, GSTT1 and GSTP1 genetic variations are not directly associated with the susceptibility to CAD in Iranian patients. Due to MDR results, there might be a non-linear association between interactions of two or three genes and smoking with CAD. There is also an association between CAD risk factors and GST variations, which requires supplementary confirmation with larger sample sizes.
Keyphrases
- coronary artery disease
- genome wide
- copy number
- risk factors
- end stage renal disease
- percutaneous coronary intervention
- coronary artery bypass grafting
- cardiovascular events
- chronic kidney disease
- ejection fraction
- newly diagnosed
- prognostic factors
- multidrug resistant
- genome wide identification
- dna methylation
- cardiovascular disease
- type diabetes
- heart failure
- gene expression
- transcription factor
- acute coronary syndrome
- atrial fibrillation
- genome wide analysis
- transcatheter aortic valve replacement