Alzheimer's disease biomarker burden in primary motor cortices is associated with poorer dexterity performance.
Lily GuptaYue MaAkshay KohliKao Lee YangJennifer M OhTobey J BetthauserNathaniel A ChinOzioma C OkonkwoMary-Elizabeth PasquesiVeena NairVivek PrabhakaranShi-Jiang LiBarbara BendlinPublished in: Alzheimer's & dementia : the journal of the Alzheimer's Association (2024)
Noted worsening dexterity performance was associated with greater Alzheimer's disease (AD) pathology (tau, amyloid beta, and neurodegeneration) in primary motor cortices. Similarly, increased neurodegeneration and tau pathology in parahippocampal, hippocampal, and entorhinal cortices is associated with worsening dexterity performance. Motor performance declined in those with clinical and preclinical AD among an array of motor assessments.