Persistent cytarabine and daunorubicin exposure after administration of novel liposomal formulation CPX-351: population pharmacokinetic assessment.
Mina NikanjamEdmund V CapparelliJeffrey E LancetArthur LouieGary SchillerPublished in: Cancer chemotherapy and pharmacology (2017)
The PK model demonstrates prolonged exposure to cytarabine and daunorubicin without increases in non-hematologic toxicity that indicates retention of the drugs within the liposome. The unique pharmacology of this formulation may allow for simplified regimens and improved outcomes.