Drug-resistant seizures associated with hyperinflammatory monocytes in FIRES.
Charles L HoweRenee K JohnsonBrittany L OverleeJessica A SagenNiyati MehtaRaquel Farias-MoellerPublished in: Annals of clinical and translational neurology (2023)
FIRES may be associated with a hyperinflammatory monocytic response to normally banal bacterial pathogens. This hyperinflammatory response may induce a profound neutrophil burden and the consequent release of factors that further exacerbate inflammation and drive neuroinflammation. Intrathecal dexamethasone may resolve RSE by resetting this inflammatory feedback loop.
Keyphrases
- drug resistant
- multidrug resistant
- oxidative stress
- acinetobacter baumannii
- gram negative
- low dose
- traumatic brain injury
- high dose
- transcription factor
- lps induced
- dendritic cells
- peripheral blood
- cognitive impairment
- risk factors
- antimicrobial resistance
- cerebral ischemia
- pseudomonas aeruginosa
- blood brain barrier