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Facile Synthesis of a MoS2-Prussian Blue Nanocube Nanohybrid-Based Electrochemical Sensing Platform for Hydrogen Peroxide and Carcinoembryonic Antigen Detection.

Shao SuXiaoyan HanZaiwei LuWei LiuDan ZhuJie ChaoChun-Hai FanLihua WangShiping SongLixing WengLian-Hui Wang
Published in: ACS applied materials & interfaces (2017)
Herein, an electrochemical detection platform was designed based on a Prussian blue nanocube-decorated molybdenum disulfide (MoS2-PBNCs) nanocomposite. Shape-controlled and high-dispersion PBNCs were supported on the MoS2 nanosheet surface, which would be simply controlled by varying the experimental conditions. Expectedly, such obtained MoS2-based nanocomposites possessed excellent electrocatalytic ability, which could be employed to construct an electrochemical sensor for nonenzymatic hydrogen peroxide (H2O2) detection. More interestingly, MoS2-PBNCs nanocomposites could be utilized to construct a sensor for label-free detection of carcinoembryonic antigen (CEA). The electrochemical response of the MoS2-based immunosensor was linear with the CEA concentration ranging from 0.005 to 10 ng mL-1. Moreover, the detection limit was calculated to be 0.54 pg mL-1. The acceptable selectivity and high stability made such immunosensors detect CEA in human serum with satisfactory results. All data indicated that this MoS2-PBNCs nanocomposite may be a promising electrochemical sensing platform for the detection of chemical and biological molecules.
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