Hepatocellular Neoplasm of Uncertain Potential of Malignancy or Well-Differentiated Hepatocellular Carcinoma Arising within Hepatocellular Adenoma.

Elisabete Campos Roberto Silva Sara Rodrigues Marinho de Almeida Joanne Lopes Marisa Aral Humberto Cristino Luís Graça Elisabete Barbosa

Published in: Case reports in surgery (2023)

HCAs share similar imaging characteristics and histopathological features with hepatocellular carcinomas; therefore, immunohistochemical and genetic studies assumes great importance to discriminate adenomas with malignant transformation. Beta-catenin, glutamine synthetase, glypican-3, and heat-shock protein 70 are promising markers to identify higher risk adenomas.

Keyphrases

heat shock protein
high resolution
heat shock
cell proliferation
epithelial mesenchymal transition
low grade
high grade
genome wide
risk assessment
dna methylation
human health
climate change
photodynamic therapy