Aspirin mediates histone methylation that inhibits inflammation-related stemness gene expression to diminish cancer stemness via COX-independent manner.
Xiaoyuan ZhangRenle DuNa LuoRong XiangWenzhi ShenPublished in: Stem cell research & therapy (2020)
The aforementioned findings suggest a molecular model that explains how aspirin diminishes cancer cell stemness properties. These findings may provide novel targets for therapeutic strategies involving aspirin in the prevention of cancer progression.
Keyphrases
- low dose
- stem cells
- gene expression
- papillary thyroid
- epithelial mesenchymal transition
- dna methylation
- cardiovascular events
- antiplatelet therapy
- squamous cell
- oxidative stress
- lymph node metastasis
- cancer stem cells
- type diabetes
- squamous cell carcinoma
- genome wide
- coronary artery disease
- percutaneous coronary intervention
- acute coronary syndrome
- single molecule