Strengthening the Evidence: Similar Rates of Neural Tube Defects Among Deliveries Regardless of Maternal HIV Status and Dolutegravir Exposure in Hospital Birth Surveillance in Eswatini.
Michelle M GillPhilisiwe KhumaloCaspian ChourayaMthokozisi KuneneFuthi DlaminiHeather J HoffmanAngela E ScheuerleBonisile NhlabatsiWiseman MngometuluNtombikayise Dlamini-MadlophaNompumelelo MthunziLynne MofensonPublished in: Open forum infectious diseases (2023)
Birth defect surveillance in Eswatini in 2020-2021 identified 0.80% defects (197/24 599 live and stillborn infants). Neural tube defect (NTD) prevalence was 0.08%, 0.08%, and 0.15% for 4902 women on dolutegravir preconception, 17 285 HIV-negative women, and 1320 women on efavirenz preconception, respectively, more definitively refuting the dolutegravir preconception NTD safety signal.
Keyphrases
- antiretroviral therapy
- pregnancy outcomes
- hiv infected
- hiv infected patients
- hiv positive
- human immunodeficiency virus
- polycystic ovary syndrome
- hiv aids
- public health
- hiv testing
- pregnant women
- cervical cancer screening
- hepatitis c virus
- healthcare
- breast cancer risk
- gestational age
- men who have sex with men
- metabolic syndrome
- insulin resistance
- type diabetes
- emergency department
- adipose tissue
- skeletal muscle