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Design and Synthesis of Novel Helix Mimetics Based on the Covalent H-Bond Replacement and Amide Surrogate.

Junyang LiuShoubin TangJia-Lei YanTao Ye
Published in: Molecules (Basel, Switzerland) (2023)
A novel hydrogen bond surrogate-based (HBS) α-helix mimetic was designed by the combination of covalent H-bond replacement and the use of an ether linkage to substitute an amide bond within a short peptide sequence. The new helix template could be placed in position other than the N -terminus of a short peptide, and the CD studies demonstrate that the template adopts stable conformations in aqueous buffer at exceptionally high temperatures.
Keyphrases
  • dna binding
  • transition metal
  • ionic liquid
  • molecularly imprinted
  • genome wide
  • gene expression
  • dna methylation
  • case control
  • visible light