Nonrandom occurrence of multiple de novo coding variants in a proband indicates the existence of an oligogenic model in autism.
Yaoqiang DuZhongshan LiZhenwei LiuNa ZhangRuochen WangFengxia LiTao ZhangYi JiangXiao ZhiZhen WangJinyu WuPublished in: Genetics in medicine : official journal of the American College of Medical Genetics (2019)
Our findings present compelling statistical evidence supporting an oligogenic model and provide new insights into the genetic architecture of ASD.