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Nonrandom occurrence of multiple de novo coding variants in a proband indicates the existence of an oligogenic model in autism.

Yaoqiang DuZhongshan LiZhenwei LiuNa ZhangRuochen WangFengxia LiTao ZhangYi JiangXiao ZhiZhen WangJinyu Wu
Published in: Genetics in medicine : official journal of the American College of Medical Genetics (2019)
Our findings present compelling statistical evidence supporting an oligogenic model and provide new insights into the genetic architecture of ASD.
Keyphrases
  • autism spectrum disorder
  • intellectual disability
  • copy number
  • risk assessment
  • attention deficit hyperactivity disorder
  • genome wide
  • dna methylation