Metabolomic fingerprint of coronary blood in STEMI patients depends on the ischemic time and inflammatory state.
Martino DeiddaCristina PirasGiulio BinaghiDamiana CongiaAlessandro PaniAlberto BoiFrancesco SannaAngelica RossiBruno LoiChristian Cadeddu DessalviLuigi AtzoriMaurizio PorcuGiuseppe MercuroPublished in: Scientific reports (2019)
In this study we investigated whether the metabolomic analysis could identify a specific fingerprint of coronary blood collected during primary PCI in STEMI patients. Fifteen samples was subjected to metabolomic analysis. Subsequently, the study population was divided into two groups according to the peripheral blood neutrophil-to-lymphocyte ratio (NLR), a marker of the systemic inflammatory response. Regression analysis was then applied separately to the two NLR groups. A partial least square (PLS) regression identified the most significant involved metabolites and the PLS-class analysis revealed a significant correlation between the metabolic profile and the total ischemic time only in patients with an NLR > 5.77.
Keyphrases
- end stage renal disease
- inflammatory response
- coronary artery disease
- newly diagnosed
- peripheral blood
- ejection fraction
- chronic kidney disease
- coronary artery
- prognostic factors
- percutaneous coronary intervention
- oxidative stress
- st segment elevation myocardial infarction
- acute coronary syndrome
- acute myocardial infarction
- patient reported outcomes
- ms ms
- single cell
- lipopolysaccharide induced
- atomic force microscopy