Trikoramide A, a Prenylated Cyanobactin from the Marine Cyanobacterium Symploca hydnoides.
Ma Yadanar PhyoChi Ying Gary DingHui Chin GohJun Xian GohJi Fa Marshall OngSiew Herng ChanPui Yi Maria YungHartono CandraLik Tong TanPublished in: Journal of natural products (2019)
A new cyclic decapeptide, trikoramide A (1), has been isolated from samples of the marine cyanobacterium Symploca hydnoides, collected from Bintan Island, Indonesia. Trikoramide A (1) is a C-prenylated cyclotryptophan-containing cyanobactin. Its planar structure was deduced by 1D and 2D NMR spectroscopy as well as HR-MS/MS data. In addition, its absolute configuration was determined by Marfey's method and 2D NOESY NMR spectroscopic analysis. Compound 1 possessed cytotoxicity against the MOLT-4 and AML2 cancer cell lines with IC50 values of 4.8 and 8.2 μM, respectively.
Keyphrases
- ms ms
- papillary thyroid
- acute myeloid leukemia
- magnetic resonance
- molecular docking
- high resolution
- electronic health record
- squamous cell
- big data
- squamous cell carcinoma
- liquid chromatography tandem mass spectrometry
- allogeneic hematopoietic stem cell transplantation
- young adults
- molecular dynamics simulations