Prenatal assessment of brain malformations on neuroimaging: an expert panel review.
Ivana PogledicKshitij MankadMariasavina SeverinoTally Lerman-SagieAndrás JakabEfrat HadiAnna C JansenNadia Bahi-BuissonNatalya Di DonatoRenske OegemaChristian MitterIvan CapoMatthew T WhiteheadParthiv HaldipurGrazia Maria Simonetta ManciniThierry A G M HuismanAndrea RighiniWilliam B DobynsJames A BarkovichNatasa Jovanov MilosevicGregor J KasprianMaarten LequinPublished in: Brain : a journal of neurology (2024)
Brain malformations represent a heterogeneous group of abnormalities of neural morphogenesis, often associated with aberrations of neuronal connectivity and brain volume. Prenatal detection of brain malformations requires a clear understanding of embryology and developmental morphology through the various stages of gestation. This expert panel review is written with the central aim of providing an easy-to-understand roadmap to improve prenatal detection and characterization of structural malformations based on the current understanding of normal and aberrant brain development. The utility of each available neuroimaging modality including prenatal multiplanar neurosonography, anatomical magnetic resonance imaging (MRI), and advanced MRI techniques, as well as further insights from post-mortem imaging have been highlighted for every developmental stage.
Keyphrases
- resting state
- white matter
- magnetic resonance imaging
- functional connectivity
- pregnant women
- cerebral ischemia
- contrast enhanced
- high resolution
- diffusion weighted imaging
- multiple sclerosis
- photodynamic therapy
- clinical practice
- gene expression
- loop mediated isothermal amplification
- brain injury
- mass spectrometry
- gestational age
- quantum dots