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Thirty-day risk of digoxin toxicity among older adults co-prescribed trimethoprim-sulfamethoxazole versus amoxicillin: A population-based cohort study.

Flory T MuandaMatthew A WeirFatemeh AhmadiEric McArthurJessica M SontropSheikh S AbdullahBrad L UrquhartHasti SadeghiRichard B KimAmit X Garg
Published in: Pharmacotherapy (2024)
In older adults taking digoxin, the 30-day risk of a hospital encounter with digoxin toxicity was nearly 6 times higher in those co-prescribed TMP-SMX versus amoxicillin, although the absolute risk difference was low (0.4%). Physicians should prescribe an alternative antibiotic when clinically appropriate. If TMP-SMX must be co-prescribed with digoxin (if the benefit is believed to outweigh the risk), digoxin should be dose-reduced on an individual basis.
Keyphrases
  • oxidative stress
  • primary care
  • healthcare
  • physical activity
  • antibiotic resistance genes
  • adverse drug
  • microbial community
  • anaerobic digestion