Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer's disease model.
Qiuchen ZhaoMegi MaciMorgan R MillerHeng ZhouFang ZhangMoustafa AlgamalYee Fun LeeSteven S HouStephen J PerleHoang LeAlyssa N RussEng H LoDmitry GerashchenkoStephen N GompertsBrian J BacskaiKsenia V KastanenkaPublished in: Molecular neurodegeneration (2023)
In summary, our study shows that optogenetic targeting of GABAergic interneurons rescues sleep, which then ameliorates neuropathological as well as behavioral deficits by increasing clearance of Aβ by microglia in an AD mouse model.