Molecular Profiling of Appendiceal Adenocarcinoma and Comparison with Right-sided and Left-sided Colorectal Cancer.

Ryuma TokunagaJoanne XiuCurtis JohnstonRichard M GoldbergPhilip A PhilipAndreas SeeberMadiha NaseemJae Ho LoHiroyuki AraiFrancesca BattaglinAlberto PucciniMartin D BergerShivani SoniWu ZhangJimmy J HwangAnthony F ShieldsJohn L MarshallHideo BabaW Michael KornHeinz-Josef Lenz

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

Molecular profiling of appendiceal adenocarcinoma revealed different molecular characteristics than noted in R-CRC and L-CRC, and molecular heterogeneity among the histopathologic subtypes of appendiceal adenocarcinoma. Our findings may be critical to developing an individualized approach to appendiceal adenocarcinoma treatment.

Keyphrases

low grade
squamous cell carcinoma
single cell
locally advanced
single molecule
high grade
rectal cancer
combination therapy