Augmented concentrations of CX3CL1 are associated with interstitial lung disease in systemic sclerosis.

Anna-Maria Hoffmann-VoldStephen Samuel WeigtVyacheslav PalchevskiyElizabeth VolkmannRajan SaggarNing LiØyvind MidtvedtMay Brit LundTorhild GarenMichael C FishbeinAbbas ArdehaliDavid J RossThor UelandPål AukrustJoseph P LynchRobert M ElashoffØyvind MolbergJohn A Belperio

Published in: PloS one (2018)

CX3CL1 is associated with progressive SSc-ILD but not SSc-PH. The CX3CR1/CX3CL1-biological axis may be involved in recruiting antibody secreting plasma cells to SSc lungs, thereby contributing to the immune-mediated pathobiology of SSc-ILD.

Keyphrases

interstitial lung disease
systemic sclerosis
rheumatoid arthritis
idiopathic pulmonary fibrosis
induced apoptosis
cell cycle arrest
multiple sclerosis
cell proliferation
cell death