RANKL interferes with osteoclastogenesis in PEG-fused U937 cells through LGR4.

Published in: Connective tissue research (2022)

Our model allows us to understand that RANKL has fusogenic activity during the first days of culture and in fused cells modulates fusion, contributing to differentiate the role of RANKL before and after fusion through LGR4.

Keyphrases

induced apoptosis
cell cycle arrest
bone loss
drug delivery
cell death
endoplasmic reticulum stress
signaling pathway
oxidative stress
immune response
cell proliferation