Dental pain report in children and genetic polymorphism (rs4818) in Catechol-O-Methyltransferase (COMT) gene: a cross- sectional study.

Bruna Leticia Vessoni Menoncin Aluhe Lopes Fatturi Rafaela Scariot Jose Vitor Nogara Borges de Menezes João Armando Brancher Juliana Feltrin de Souza

Published in: Journal of applied oral science : revista FOB (2024)

The rs4818 polymorphism of the COMT gene is associated with dental pain. Children with the C allele are more likely to report higher levels of pain. Clinical Relevance: Even though the experience of pain is subjective and multifactorial, this study raises the hypothesis that there is a genetic predisposition to dental pain that should be considered in clinical practice.

Keyphrases

chronic pain
pain management
neuropathic pain
genome wide
copy number
clinical practice
young adults
gene expression
dna methylation
postoperative pain
sleep quality