Concomitant Proton Pump Inhibitor Use and Survival in Urothelial Carcinoma Treated with Atezolizumab.

Ashley M HopkinsGanessan KichenadasseChristos S KarapetisAndrew RowlandMichael J Sorich

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

This study indicates PPI use is a negative prognostic marker in advanced urothelial carcinoma treated with ICI therapy, but not chemotherapy. Furthermore, the analysis suggests PPIs influence the magnitude of ICI efficacy, and this warrants further investigation.

Keyphrases

locally advanced
radiation therapy