The road to reliable peptide assays is paved with good guidelines.
Jonathan MaurerEric GrouzmannPhilippe J EugsterPublished in: Clinical endocrinology (2022)
Kowalka et al. recently validated a new Liquid Chomatography Tandem Mass Spectrometry (LC-MS/MS) assay for PYY1-36 and PYY3-36 in human plasma using three different guidelines: the 2018 Food and Drug Administration (FDA) guideline for bioanalytical method validation, the 2014 Clinical and Laboratory Standards Institute (CLSI) C62-A guideline, and the penultimate 2011 European Medicines Agency (EMA) guideline on bioanalytical method validation updated in 2015 1 This article is protected by copyright. All rights reserved.
Keyphrases
- tandem mass spectrometry
- drug administration
- ultra high performance liquid chromatography
- high performance liquid chromatography
- liquid chromatography
- high throughput
- gas chromatography
- simultaneous determination
- clinical practice
- solid phase extraction
- high resolution
- mass spectrometry
- high resolution mass spectrometry
- ionic liquid
- human health
- risk assessment
- climate change