Antibody avidity maturation, following recovery from infection or the booster vaccination, grants breadth in SARS-CoV-2 neutralizing capacity.

Yu NakagamaKatherine CandrayNatsuko KakuYuko KomaseMaria-Virginia Rodriguez-FunesRhina DominguezTomoya TsuchidaHiroyuki KunishimaEtsuko NagaiEisuke AdachiDieudonné Mumba NgoyiMari YamasueKosaku KomiyaKazufumi HiramatsuNaoto UemuraYuki SugiuraMayo YasugiYuka YamagishiHiroshige MikamoSatoshi ShiraishiTakehiro IzumoSachie NakagamaChihiro WatanabeYuko NitaharaEvariste Tshibangu-KabambaHiroshi KakeyaYasutoshi Kido

Published in: The Journal of infectious diseases (2022)

Avidity maturation was progressive beyond acute recovery from infection, or became apparent after the booster vaccine dose, granting broader anti-SARS-CoV-2 neutralizing capacity. Understanding the maturation kinetics of the two building blocks of anti-SARS-CoV-2 humoral immunity is crucial.

Keyphrases

sars cov
respiratory syndrome coronavirus
immune response
dengue virus
liver failure
multiple sclerosis
magnetic resonance
zika virus
intensive care unit
coronavirus disease
aedes aegypti
aqueous solution