The transcription factor PDR-1 is a multi-functional regulator and key component of pectin deconstruction and catabolism in Neurospora crassa.
Nils ThiemeVincent W WuAxel DietschmannAsaf A SalamovMei WangJenifer JohnsonVasanth R SinganIgor V GrigorievN Louise GlassChris R SomervilleJ Philipp BenzPublished in: Biotechnology for biofuels (2017)
PDR-1 is highly conserved in filamentous ascomycete fungi and is present in many pathogenic and industrially important fungi. Our data demonstrate that the function of PDR-1 in N. crassa combines features of two recently described transcription factors in Aspergillus niger (RhaR) and Botrytis cinerea (GaaR). The results presented in this study contribute to a broader understanding of how pectin degradation is orchestrated in filamentous fungi and how it could be manipulated for optimized pectinase production.