Login / Signup

Excess of singleton loss-of-function variants in Parkinson's disease contributes to genetic risk.

Dheeraj Reddy BobbiliPeter BandaRejko KrügerPatrick May
Published in: Journal of medical genetics (2020)
The main finding of this study is to highlight the contribution of singleton loss-of-function variants to the complex genetics of PD and that disease risk prediction models combining singleton and common variants can improve models built solely on common variants.
Keyphrases
  • copy number
  • preterm birth
  • gestational age
  • birth weight
  • genome wide
  • dna methylation
  • gene expression
  • body mass index
  • weight gain
  • breast cancer risk