Pulmonary delivery of flecainide causes a rate-dependent predominant effect on atrial compared with ventricular depolarization duration revealed by intracardiac recordings in an intact porcine model.
Victor Z de AntonioAnderson C SilvaFernando G StoccoBruna A SilvaAlexandre A MarumAlexandre L BortolottoLuiz BelardinelliRichard L VerrierPublished in: Journal of cardiovascular electrophysiology (2018)
Intratracheal flecainide exerts a rate-dependent, predominant effect on atrial compared with ventricular depolarization duration. Pulmonary delivery of flecainide could facilitate AF conversion to sinus rhythm with reduced ventricular proarrhythmia risk.