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Effects of blood storage age on immune, coagulation, and nitric oxide parameters in transfused patients undergoing cardiac surgery.

Philip C SpinellaRoman M SniecinskiFelicia TrachtenbergHeather C InglisGayatri RanganathanJohn W HeitmanFania SzlamAli DaneshMars StoneSheila M KeatingJerrold H LevySusan F AssmannMarie E SteinerAllan DoctorPhillip J Norris
Published in: Transfusion (2019)
Transfusion of fresh versus aged RBCs does not result in substantial changes in hemostasis, immune, or nitric oxide parameters. It is possible that transfusion modulates the level of platelet-derived extracellular vesicles, which will require study of patients randomly assigned to receipt of transfusion to define.
Keyphrases
  • cardiac surgery
  • nitric oxide
  • acute kidney injury
  • patients undergoing
  • nitric oxide synthase
  • hydrogen peroxide
  • sickle cell disease