In vitro and In vivo Assessment of Suitable Reference Region and Kinetic Modelling for the mGluR1 Radioligand [11C]ITDM in Mice.

Daniele BertoglioJeroen VerhaegheŠpela KoratAlan MirandaLeonie WyffelsSigrid StroobantsLadislav MrzljakCelia DominguezLongbin LiuMette SkinbjergIgnacio Munoz-SanjuanSteven Staelens

Published in: Molecular imaging and biology (2021)

No suitable reference region could be identified for [11C]ITDM as strongly supported by in vivo and in vitro evidence of specific binding in all brain regions. However, by applying appropriate kinetic models, [11C]ITDM PET imaging represents a promising tool to visualize mGluR1 in the mouse brain.

Keyphrases

pet imaging
positron emission tomography
resting state
white matter
high fat diet induced
computed tomography
multiple sclerosis
dna binding
functional connectivity
binding protein
brain injury