Cardiometabolic disease, cognitive decline, and brain structure in middle and older age.

Abigail DoveJie GuoJiao WangDavide Liborio VetranoSakura SakakibaraErika J LaukkaDavid A BennettWeili Xu

Published in: Alzheimer's & dementia (Amsterdam, Netherlands) (2024)

We explored the association of CMDs with cognitive decline and brain MRI measures.CMDs accelerated cognitive decline in older (≥60y) but not middle (<60) age.CMDs were associated with poorer brain MRI parameters in both middle and older age.Results highlight the connection between CMDs and cognitive/brain aging.

Keyphrases

cognitive decline
mild cognitive impairment
resting state
white matter
functional connectivity
magnetic resonance imaging
physical activity
middle aged
cerebral ischemia
contrast enhanced
computed tomography
blood brain barrier
subarachnoid hemorrhage