Major histocompatibility complexes are up-regulated in glomerular endothelial cells via activation of c-Jun N-terminal kinase in 5/6 nephrectomy mice.

Dong ZhuQunye TangBaixue YuMei MengWenjie LiuJiawei LiTongyu ZhuPaul M VanhoutteSusan W S Leung Yi Zhang Yi Shi

Published in: British journal of pharmacology (2020)

Chronic inflammation in mice subjected to nephrectomy induces the up-regulation of MHC molecules in glomerular endothelial cells. This up-regulation is reduced by inhibition of JNK signalling.

Keyphrases

endothelial cells
high glucose
high fat diet induced
robot assisted
oxidative stress
editorial comment
signaling pathway
cell death
vascular endothelial growth factor
transcription factor
type diabetes
metabolic syndrome
insulin resistance
protein kinase
endoplasmic reticulum stress